Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.

@article{Gorska1998DominantnegativeIO,
  title={Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.},
  author={A E Gorska and Heather Dalterio Joseph and Rik Derynck and Harold L. Moses and Rosa A Serra},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1998},
  volume={9 3},
  pages={229-38}
}
Transforming growth factor (TGF)-beta1 and TGF-beta3 are normally expressed at high levels in the mammary gland during quiescence and at all stages of development, except lactation. Exogenously added TGF-beta1, -beta2, and -beta3 have been shown to regulate growth and differentiation of mammary epithelial cells in vitro and in vivo. TGF-betas signal through a heteromeric complex of type I and type II serine/threonine kinases. The type II receptor is necessary for ligand binding and growth… CONTINUE READING