Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B.

@article{Neznanov2003DominantNF,
  title={Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B.},
  author={Nickolay Neznanov and Lubov Neznanova and Roman V. Kondratov and Ludmila G Burdelya and Eugene S. Kandel and Donald M. O'Rourke and Axel Ullrich and Andrei V. Gudkov},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 6},
  pages={3809-15}
}
Genetic suppressor element (GSE) methodology was applied to identify new genes controlling cell response to tumor necrosis factor (TNF). A retroviral library of randomly fragmented normalized cDNA from mouse fibroblasts was screened for GSEs capable of protecting NIH3T3 cells from TNF-induced apoptosis. The most abundant among isolated GSEs represented a fragment of cDNA encoding the C-terminal cytoplasmic region of the immunoglobulin family inhibitory receptor, SHPS-1 (mouse homologue of human… CONTINUE READING

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