Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.

@article{Herbach2007DominantnegativeEO,
  title={Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.},
  author={Nadja Herbach and Birgit Rathkolb and Elisabeth Kemter and Lisa Pichl and Matthias Klaften and Martin Hrabe de Angelis and Philippe A. Halban and Eckhard Wolf and Bernhard Aigner and Ruediger Wanke},
  journal={Diabetes},
  year={2007},
  volume={56 5},
  pages={1268-76}
}
The novel diabetic mouse model Munich Ins2(C95S) was discovered within the Munich N-ethyl-N-nitrosourea mouse mutagenesis screen. These mice exhibit a T-->A transversion in the insulin 2 (Ins2) gene at nucleotide position 1903 in exon 3, which leads to the amino acid exchange C95S and loss of the A6-A11 intrachain disulfide bond. From 1 month of age onwards, blood glucose levels of heterozygous Munich Ins2(C95S) mutant mice were significantly increased compared with controls. The fasted and… CONTINUE READING