Dominant negative effects of a non-conducting TREK1 splice variant expressed in brain.

@article{Veale2010DominantNE,
  title={Dominant negative effects of a non-conducting TREK1 splice variant expressed in brain.},
  author={Emma L Veale and Kathryn A Rees and Alistair Mathie and Stefan A J Trapp},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 38},
  pages={29295-304}
}
Two-pore domain potassium (K(2P)) channels modulate neuronal excitability throughout the entire CNS. The stretch-activated channel TREK1 (K(2P)2.1) is expressed widely in brain and has been linked to depression, neuroprotection, pain perception, and epilepsy. Little, however, is known about the regulation of TREK1 expression on the transcriptional and translational level or about its trafficking to the plasma membrane. Here we have used PCR techniques to identify a splice variant of TREK1… CONTINUE READING