Dominant-negative beta1 integrin mice have region-specific myelin defects accompanied by alterations in MAPK activity.

@article{Lee2006DominantnegativeBI,
  title={Dominant-negative beta1 integrin mice have region-specific myelin defects accompanied by alterations in MAPK activity.},
  author={Karen K Lee and Yves de Repentigny and Ron Saulnier and Peter U Rippstein and Wendy B Macklin and Rashmi Kothary},
  journal={Glia},
  year={2006},
  volume={53 8},
  pages={836-44}
}
Recent studies have demonstrated the importance of beta1 integrin in oligodendrocyte maturation in vitro. Similar studies in vivo have been difficult due to the embryonic and perinatal lethality of null mutations in integrin subunits. Here, we have generated transgenic mouse models that overexpress full length beta1 integrin or express a dominant-negative beta1 integrin DeltaC (lacking the C-terminal tail) under the control of the proteolipid protein (PLP) promoter. We demonstrate that these… CONTINUE READING
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