Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.

@article{Haruki2005DominantnegativeNR,
  title={Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.},
  author={Nobuhiro Haruki and Keiko S Kawaguchi and Shannon Eichenberger and Pierre P. Massion and Sandra Jean Olson and Adriana Vilchis Gonzalez and David Paul Carbone and Thao P. Dang},
  journal={Cancer research},
  year={2005},
  volume={65 9},
  pages={3555-61}
}
Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both vertebrates and invertebrates. Significant data support the role of Notch pathway in cancer development, although the conflicting role of Notch signaling pathways in tumorigenesis suggests that its action is highly context-dependent. Furthermore, although Notch receptors signal primarily through the regulation of hairy enhancer of split (HES) and HES-related (HRT… CONTINUE READING

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Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.

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