Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.

@article{Hikida2007DominantnegativeDT,
  title={Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.},
  author={Takatoshi Hikida and Hanna Jaaro-Peled and Saurav Seshadri and Kenichi Oishi and Caroline Hookway and Stephanie Kong and Di Wu and Rong Xue and Manuella Andrad{\'e} and Stephanie K. Tankou and Susumu Mori and Michela Gallagher and Koko Ishizuka and Mikhail Pletnikov and Satoshi Kida and Akira Sawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 36},
  pages={14501-6}
}
Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1) genetically engineered mice as a potential model for major mental illnesses, such as schizophrenia. DISC1 is a promising genetic risk factor for major mental illnesses. In this transgenic model, a dominant-negative form of DISC1 (DN-DISC1) is expressed under the alphaCaMKII promoter. In vivo MRI of the DN-DISC1 mice detected enlarged lateral ventricles particularly on the left side, suggesting a link to the… CONTINUE READING
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