Dominant maternal-effect mutations causing embryonic lethality in Caenorhabditis elegans.

@article{Mains1990DominantMM,
  title={Dominant maternal-effect mutations causing embryonic lethality in Caenorhabditis elegans.},
  author={Paul E Mains and I A Sulston and William B. Wood},
  journal={Genetics},
  year={1990},
  volume={125 2},
  pages={351-69}
}
We undertook screens for dominant, temperature-sensitive, maternal-effect embryonic-lethal mutations of Caenorhabditis elegans as a way to identify certain classes of genes with early embryonic functions, in particular those that are members of multigene families and those that are required in two copies for normal development. The screens have identified eight mutations, representing six loci. Mutations at three of the loci result in only maternal effects on embryonic viability. Mutations at… CONTINUE READING

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