Dominant lethal study of ribavirin in male rats.

@article{Hoffmann1987DominantLS,
  title={Dominant lethal study of ribavirin in male rats.},
  author={Stanley H. Hoffmann and Michael J. Wade and Judy Staffa and Douglas Mcgregor and M. Holmstrom and Anthony Dayan},
  journal={Mutation research},
  year={1987},
  volume={188 1},
  pages={
          29-34
        }
}
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17 Citations
Background Citations
8
Results Citations
2

17 Citations

The antiviral drug ribavirin reversibly affects the reproductive parameters in the male Wistar rat.
TLDR
Ribavirin is gonadotoxic in male rats but the effects are reversible after a period of 105 days, however, the endocrine-disrupting properties of ribavirin persist beyond this period.
Ribavirin-induced sperm shape abnormalities in Wistar rat.
Effect of ribavirin on epididymal sperm count in rat.
TLDR
Ribavirin significantly decreased the sperm count in a dose and time dependent pattern and showed a recovery by day 105 except at 200 mg/kg, indicating reversibly cytotoxic to germ cells and decreases the production of spermatozoa.
Cytogenetic effects of ribavirin on mouse bone marrow.
Genotoxic effect of ribavirin in patients with Crimean-Congo hemorrhagic fever.
TLDR
The results of this study reveal that ribavirin has a reversible in vivo genotoxic effect on humans.
Evaluation of the role of the antioxidant silymarin in modulating the in vivo genotoxicity of the antiviral drug ribavirin in mice.
Evaluation of Ribavirin Genotoxicity with Sister Chromatid Exchange and Micronuclei Assays in Humans
TLDR
Ribavirin has a reversible genotoxic effect in humans and this effect could be due to toxic metabolites of ribavirin.
Use of Cotton Rats to Evaluate the Efficacy of Antivirals in Treatment of Measles Virus Infections
TLDR
Cotton rats may indeed be useful for the initial evaluation of the activities of antiviral agents against measles virus, and two compounds that have been reported to inhibit MV in vitro are evaluated.
In vivo chromosome damaging effects of an inosine monophosphate dehydrogenase inhibitor: Ribavirin in mice
TLDR
Ribavirin is a potent mutagen and cytotoxic agent in mice in vivo and it also induces point mutations in germ cells yielding abnormal sperms, indicating that it prevents cell division in mouse bone marrow.
Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection.
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References

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