Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration.

@article{Milam2000DominantLR,
  title={Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration.},
  author={Ann H. Milam and Christine A. Curcio and Artur V. Cideciyan and Sandeep K Saxena and Sinoj K John and Howard S. Kruth and Goldis Malek and John R. Heckenlively and Richard G. Weleber and Samuel G. Jacobson},
  journal={Ophthalmology},
  year={2000},
  volume={107 12},
  pages={2256-66}
}
PURPOSE To clarify the pathogenesis of late-onset retinal degeneration (L-ORD), an autosomal dominant disorder characterized by thick deposits of lipid-rich material between the retinal pigment epithelium (RPE) and Bruch's membrane. STUDY DESIGN Comparative clinicopathologic case report and case series. TISSUES: Eyes of an 82-year-old L-ORD eye donor and an age-matched control. SUBJECTS Five descendants of the eye donor and his affected sister. METHODS The eyes were processed for… CONTINUE READING

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