Dominant inhibitory Ras delays Sindbis virus-induced apoptosis in neuronal cells.

@article{Joe1996DominantIR,
  title={Dominant inhibitory Ras delays Sindbis virus-induced apoptosis in neuronal cells.},
  author={Andrew K. Joe and Giuliana Ferrari and Hai Hua Jiang and Xiao Huan Liang and Beth Levine},
  journal={Journal of virology},
  year={1996},
  volume={70 11},
  pages={7744-51}
}
Mature neurons are more resistant than dividing cells or differentiating neurons to Sindbis virus-induced apoptotic death. Therefore, we hypothesized that mitogenic signal transduction pathways may influence susceptibility to Sindbis virus-induced apoptosis. Since Ras, a 21-kDa GTP-binding protein, plays an important role in cellular proliferation and neuronal differentiation, we investigated the effect of an inducible dominant inhibitory Ras on Sindbis virus-induced death of a rat… CONTINUE READING

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