Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus.

@article{Dunn2011DominantIO,
  title={Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus.},
  author={Ewan F Dunn and John H. Connor},
  journal={Journal of virology},
  year={2011},
  volume={85 1},
  pages={
          422-31
        }
}
Vesicular stomatitis virus (VSV) is a rhabdovirus that alters host nuclear and cytoplasmic function upon infection. We have investigated the effect of VSV infection on cellular signaling through the phosphatidylinositol-3 kinase (PI3k)/Akt signaling pathway. Akt phosphorylation at both threonine 308 (Thr308) and serine 473 (Ser473) was inhibited in cells infected with VSV. This inhibition was rapid (beginning within the first 2 to 3 h postinfection) and correlated with the dephosphorylation of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 67 REFERENCES

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1999
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Role of translocation in the activation and function of protein kinase B.

  • The Journal of biological chemistry
  • 1997
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

The nuts and bolts of AGC protein kinases

  • Nature Reviews Molecular Cell Biology
  • 2010
VIEW 1 EXCERPT