Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice

  title={Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice},
  author={Yan Li and Sheila J. Semaan and Cassandra L. Schlamp and Robert W Nickells},
  journal={BMC Neuroscience},
  pages={19 - 19}
Several neurodegenerative diseases are influenced by complex genetics that affect an individual's susceptibility, disease severity, and rate of progression. One such disease is glaucoma, a chronic neurodegenerative condition of the eye that targets and stimulates apoptosis of CNS neurons called retinal ganglion cells. Since ganglion cell death is intrinsic, it is reasonable that the genes that control this process may contribute to the complex genetics that affect ganglion cell susceptibility… CONTINUE READING


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Differential regulation of the pro-apoptotic gene Bax in DBA/2J and 129B6 inbred mice affects retinal ganglion cell death after optic nerve crush

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