Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II.

@article{Shi2008DominantAP,
  title={Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II.},
  author={Jing Shi and Shizhong Bao and Jun Yin and Kun Cai and Xiaojun Hou and Le Xiao and Wei Hong Tu and Qin Wang and Hui Wang},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={374 2},
  pages={331-5}
}
Botulism toxicity is caused by botulinum neurotoxins (BoNTs) that bind to the surface of the nerve terminals through the C-terminal portion of the heavy chain (Hc) and gain access to the neuron cells, thereby blocking the release of neurotransmitters into the synapse by the light chain. It has been recently found that synaptotagmin II (syt II) is the specific protein receptor of BoNTs; however, the molecular basis underlying the interaction between BoNTs and the receptor has been poorly… CONTINUE READING