Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.

@article{Tatarakis2008DominantAR,
  title={Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.},
  author={Antonis Tatarakis and Thanasis Margaritis and Celia Pilar Martinez-Jimenez and Antigone Kouskouti and William S Mohan and Anna Haroniti and Dimitris Kafetzopoulos and L{\'a}szl{\'o} Tora and Iannis Talianidis},
  journal={Molecular cell},
  year={2008},
  volume={31 4},
  pages={531-43}
}
To study the in vivo role of TFIID in the transcriptional regulation of hepatic genes, we generated mice with liver-specific disruption of the TAF10 gene. Inactivation of TAF10 in hepatocytes resulted in the dissociation of TFIID into individual components. This correlated with the downregulation of most hepatocyte-specific genes during embryonic life and a defect in liver organogenesis. Unexpectedly, however, the transcription of less than 5% of active genes was affected by TAF10 inactivation… CONTINUE READING

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