Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2.

@article{Joshi2008DominantAI,
  title={Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2.},
  author={Preeti Joshi and Elizabeth A Carrington and Liangjun Wang and Carrie S. Ketel and Ellen L. Miller and Richard S. Jones and Jeffrey A. Simon},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 41},
  pages={27757-66}
}
Polycomb gene silencing requires histone methyltransferase activity of Polycomb repressive complex 2 (PRC2), which methylates lysine 27 of histone H3. Information on how PRC2 works is limited by lack of structural data on the catalytic subunit, Enhancer of zeste (E(Z)), and the paucity of E(z) mutant alleles that alter its SET domain. Here we analyze missense alleles of Drosophila E(z), selected for molecular study because of their dominant genetic effects. Four missense alleles identify key E… CONTINUE READING

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