Dominant activity of activation function 1 (AF-1) and differential stoichiometric requirements for AF-1 and -2 in the estrogen receptor alpha-beta heterodimeric complex.

@article{Tremblay1999DominantAO,
  title={Dominant activity of activation function 1 (AF-1) and differential stoichiometric requirements for AF-1 and -2 in the estrogen receptor alpha-beta heterodimeric complex.},
  author={Gilles B. Tremblay and Annie M Tremblay and Fernand Labrie and Vincent Gigu{\`e}re},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 3},
  pages={1919-27}
}
Estrogenic responses are now known to be mediated by two forms of estrogen receptors (ER), ERalpha and ERbeta, that can function as homodimers or heterodimers. As homodimers the two have been recently shown to exhibit distinct transcriptional responses to estradiol (E2), antiestrogens, and coactivators, suggesting that the ER complexes are not functionally… CONTINUE READING