Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin

@inproceedings{Ross2015DominantSO,
  title={Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin},
  author={Ewan Ross and Tim Smallie and Qize Ding and John D. O’Neil and Helen E. Cunliffe and Tina M Y Tang and Dalya R. Rosner and Iva Klevernic and Nicholas A. Morrice and Claudia Monaco and Adam F Cunningham and Christopher D Buckley and Jeremy Saklatvala and Jonathan L. E. Dean and A R Clark},
  booktitle={Journal of immunology},
  year={2015}
}
In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178, we created a mouse strain in which those residues were replaced by nonphosphorylatable alanine residues. The mutant form of TTP was constitutively degraded by the proteasome and therefore expressed at low levels, yet it functioned as a potent mRNA destabilizing factor and inhibitor of… CONTINUE READING
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