Dominant Negative Mutants of Bacillus thuringiensis Cry1Ab Toxin Function as Anti-Toxins: Demonstration of the Role of Oligomerization in Toxicity

@article{RodrguezAlmazn2009DominantNM,
  title={Dominant Negative Mutants of Bacillus thuringiensis Cry1Ab Toxin Function as Anti-Toxins: Demonstration of the Role of Oligomerization in Toxicity},
  author={Claudia Rodr{\'i}guez-Almaz{\'a}n and Luis Enrique Zavala and Carlos Mu{\~n}{\'o}z-Garay and Nuria Jim{\'e}nez-Ju{\'a}rez and Sabino Pacheco and Luke Masson and Mario Sober{\'o}n and Alejandra Bravo},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={775 - 806}
}
BACKGROUND Bacillus thuringiensis Cry toxins, that are used worldwide in insect control, kill insects by a mechanism that depends on their ability to form oligomeric pores that insert into the insect-midgut cells. These toxins are being used worldwide in transgenic plants or spray to control insect pests in agriculture. However, a major concern has been the possible effects of these insecticidal proteins on non-target organisms mainly in ecosystems adjacent to agricultural fields. METHODOLOGY… CONTINUE READING

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