Dominant-Negative Androgen Receptor Inhibition of Intracrine Androgen-Dependent Growth of Castration-Recurrent Prostate Cancer

@inproceedings{Titus2012DominantNegativeAR,
  title={Dominant-Negative Androgen Receptor Inhibition of Intracrine Androgen-Dependent Growth of Castration-Recurrent Prostate Cancer},
  author={Mark A. Titus and Brian Zeithaml and Boris Kantor and Xiangping Li and Karin Haack and Dominic T. Moore and Elizabeth M. Wilson and James L. Mohler and Tal Kafri},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Prostate cancer (CaP) is the second leading cause of cancer death in American men. Androgen deprivation therapy is initially effective in CaP treatment, but CaP recurs despite castrate levels of circulating androgen. Continued expression of the androgen receptor (AR) and its ligands has been linked to castration-recurrent CaP growth. PRINCIPAL FINDING In this report, the ligand-dependent dominant-negative ARΔ142-337 (ARΔTR) was expressed in castration-recurrent CWR-R1 cell and… CONTINUE READING
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