Dominant Cross-reactive Antibodies Generated during the Response to a Variety of Oral Bacterial Species Detect Phosphorylcholine

@article{Gmur1999DominantCA,
  title={Dominant Cross-reactive Antibodies Generated during the Response to a Variety of Oral Bacterial Species Detect Phosphorylcholine},
  author={Rudolf Gmür and T. Thumheer and Bernhard Prof Dr Guggenheim},
  journal={Journal of Dental Research},
  year={1999},
  volume={78},
  pages={77 - 85}
}
The intraperitoneal immunization of Balb/c mice with subgingival plaque from advanced periodontal pockets or with certain strains of Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Actinomyces israelii, Streptococcus mitis, or Streptococcus oralis yielded frequently indistinguishable IgM monoclonal antibodies which were reactive with antigens from a variety of oral bacteria. This study aimed to characterize the specificity of such monoclonal antibodies and the diversity of oral… 
Induction of immune response to Streptococcus pneumoniae by administration of oral viridans streptococci via phosphorylcholine determinant.
TLDR
The present results indicate the possibility that PC-expressing oral commensal bacteria have a significant influence on the hosts' responsiveness to S. pneumoniae.
Opsonization of Actinobacillus actinomycetemcomitans by Immunoglobulin G Antibody Reactive with Phosphorylcholine
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Phosphorylcholine-Dependent Cross-Reactivity between Dental Plaque Bacteria and Oxidized Low-Density Lipoproteins
TLDR
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Study of Humoral Immunity to Commensal Oral Bacteria in Human Infants Demonstrates the Presence of Secretory Immunoglobulin A Antibodies Reactive with Actinomyces naeslundii Genospecies 1 and 2 Ribotypes
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Locally produced anti-phosphorylcholine and anti-oxidized low-density lipoprotein antibodies in gingival crevicular fluid from aggressive periodontitis patients.
TLDR
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TLDR
It is concluded that P. gingivalis HSP 60 could potentially be developed as a vaccine against multiple periodontopathic bacteria.
Phosphorylcholine is located in Aggregatibacter actinomycetemcomitans fimbrial protein Flp 1
TLDR
The results suggest that a third of rough-colony strains harbor ChoP and that ChoP is attached to fimbrial subunit protein Flp1, which may reduce A. actinomycetemcomitans susceptibility to serum killing.
Serum IgG1 and IgG2 antibody responses to Porphyromonas gingivalis in patients with periodontitis.
TLDR
Investigation of serum IgG1 and IgG2 antibody responses of periodontitis patients to protein and carbohydrate-rich antigens of P. gingivalis found much of the response to carbohydrate antigen is of the IgG 2 subclass.
Antiphosphorylcholine Antibody Levels Are Elevated in Humans with Periodontal Diseases
TLDR
The data show that many commonly occurring bacterial species found in dental plaque contain PC antigen and that immunization with plaque-derived PC antigens as a consequence of inflammation and periodontal attachment loss may influence systemic anti-PC antibody concentrations.
Recognition of Porphyromonas gingivalis Gingipain Epitopes by Natural IgM Binding to Malondialdehyde Modified Low-Density Lipoprotein
TLDR
A role for natural antibodies in the pathogenesis of two related inflammatory diseases, atherosclerosis and periodontitis is suggested.
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