Dominant Cross-Reactive B Cell Response during Secondary Acute Dengue Virus Infection in Humans


The four serotypes of dengue virus (DENV) cause dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Severe disease has been associated with heterotypic secondary DENV infection, mediated by cross-reactive antibodies (Abs) and/or cross-reactive T cells. The role of cross-reactive immunity in mediating enhanced disease versus cross… (More)
DOI: 10.1371/journal.pntd.0001568


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