Dominance of the lurcher mutation in heteromeric kainate and AMPA receptor channels.

@article{Schwarz2001DominanceOT,
  title={Dominance of the lurcher mutation in heteromeric kainate and AMPA receptor channels.},
  author={Milan Schwarz and Verena Pawlak and Pavel Osten and Volker Mack and P. H. Seeburg and Georg K{\"o}hr},
  journal={The European journal of neuroscience},
  year={2001},
  volume={14 5},
  pages={861-8}
}
Homomeric glutamate receptor (GluR) channels become spontaneously active when the last alanine residue within the invariant SYTANLAAF-motif in the third membrane segment is substituted by threonine. The same mutation in the orphan GluRdelta2 channel is responsible for neurodegeneration in "Lurcher" (Lc) mice. Since most native GluRs are composed of different subunits, we investigated the effect of an Lc-mutated subunit in heteromeric kainate and AMPA receptors expressed in HEK293 cells. Kainate… CONTINUE READING
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