Dominance of SOX9 function over RUNX2 during skeletogenesis.

  title={Dominance of SOX9 function over RUNX2 during skeletogenesis.},
  author={Guang Zhou and Qiping Zheng and Feyza Engin and Elda M. Munivez and Yuqing Chen and Eiman T Sebald and Deborah Krakow and Brendan Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 50},
Mesenchymal stem cell-derived osteochondroprogenitors express two master transcription factors, SOX9 and RUNX2, during condensation of the skeletal anlagen. They are essential for chondrogenesis and osteogenesis, respectively, and their haploinsufficiency causes human skeletal dysplasias. We show that SOX9 directly interacts with RUNX2 and represses its activity via their evolutionarily conserved high-mobility-group and runt domains. Ectopic expression of full-length SOX9 or its RUNX2… CONTINUE READING
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