Domains of high Ca2+ beneath the plasma membrane of living A7r5 cells.

@article{Marsault1997DomainsOH,
  title={Domains of high Ca2+ beneath the plasma membrane of living A7r5 cells.},
  author={Robert Marsault and Marta Murgia and Tullio Pozzan and Rosario Rizzuto},
  journal={The EMBO journal},
  year={1997},
  volume={16 7},
  pages={1575-81}
}
Theoretical models and indirect experimental observations predict that Ca2+ concentrations at the inner surface of the plasma membrane may reach, upon stimulation, values much higher than those of the bulk cytosol. In the past few years, we have shown that the Ca2+-sensitive photoprotein aequorin can be intracellularly targeted and utilized for specifically monitoring the [Ca2+] of various organelles. In this work, we extend this approach to the study of the cytoplasmic rim beneath the plasma… CONTINUE READING

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