Domain-wide regulation of gene expression in the human genome.

  title={Domain-wide regulation of gene expression in the human genome.},
  author={Hinco J Gierman and Mireille H G Indemans and Jan Koster and Sandra Goetze and Jurgen Seppen and Dirk Geerts and Roel van Driel and Rogier Versteeg},
  journal={Genome research},
  volume={17 9},
Transcription factor complexes bind to regulatory sequences of genes, providing a system of individual expression regulation. Targets of distinct transcription factors usually map throughout the genome, without clustering. Nevertheless, highly and weakly expressed genes do cluster in separate chromosomal domains with an average size of 80-90 genes. We therefore asked whether, besides transcription factors, an additional level of gene expression regulation exists that acts on chromosomal domains… CONTINUE READING
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