Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites.

@article{Chen2008DomainswappedDO,
  title={Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites.},
  author={Jia Jie Chen and Lifeng Pan and Zhiyi Wei and Yanxiang Zhao and Mingjie Zhang},
  journal={The EMBO journal},
  year={2008},
  volume={27 15},
  pages={2113-23}
}
PDZ domain scaffold proteins are capable of assembling macromolecular protein complexes in diverse cellular processes through PDZ-mediated binding to a short peptide fragment at the carboxyl tail of target proteins. How each PDZ domain specifically recognizes its target protein(s) remains a major conceptual question, as at least a few out of the several hundred PDZ domains in each eukaryotic genome share overlapping binding properties with any given target protein. Here, we show that the domain… CONTINUE READING

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