Domain structure of the basement membrane heparan sulfate proteoglycan.

  title={Domain structure of the basement membrane heparan sulfate proteoglycan.},
  author={S R Ledbetter and Larry W. Fisher and J. Hassell},
  volume={26 4},
We have used proteolytic digestions and immunological reactivity to map regional domains of the 400-kilodalton (kDa) core protein of the heparan sulfate containing basement membrane proteoglycan from the Englebreth-Holm-Swarm tumor. Digestion with V8 protease caused the rapid release of numerous large peptides ranging in size from 80 to 200 kDa and a 44-kDa peptide. The 44-kDa peptide (P44) was stable to further digestion, but the larger peptides were eventually degraded to a 46-kDa peptide… CONTINUE READING


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