Domain structure of the DEMETER 5-methylcytosine DNA glycosylase.

  title={Domain structure of the DEMETER 5-methylcytosine DNA glycosylase.},
  author={Young Geun Mok and Rie Uzawa and Jiyoon Lee and Gregory M. Weiner and Brandt F Eichman and Robert L. Fischer and Jin Hoe Huh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 45},
DNA glycosylases initiate the base excision repair (BER) pathway by excising damaged, mismatched, or otherwise modified bases. Animals and plants independently evolved active BER-dependent DNA demethylation mechanisms important for epigenetic reprogramming. One such DNA demethylation mechanism is uniquely initiated in plants by DEMETER (DME)-class DNA glycosylases. Arabidopsis DME family glycosylases contain a conserved helix-hairpin-helix domain present in both prokaryotic and eukaryotic DNA… CONTINUE READING