Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA.

@article{Yu2001DomainSA,
  title={Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA.},
  author={Xiong Wen Yu and Steven A. Jacobs and Stephen C West and Takeshi Ogawa and Edward H. Egelman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 15},
  pages={8419-24}
}
Both the bacterial RecA protein and the eukaryotic Rad51 protein form helical nucleoprotein filaments on DNA that catalyze strand transfer between two homologous DNA molecules. However, only the ATP-binding cores of these proteins have been conserved, and this same core is also found within helicases and the F1-ATPase. The C-terminal domain of the RecA protein forms lobes within the helical RecA filament. However, the Rad51 proteins do not have the C-terminal domain found in RecA, but have an N… CONTINUE READING