Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin.

@article{Viviano2004DomainspecificMO,
  title={Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin.},
  author={Beth L. Viviano and Stephenie Paine-Saunders and Nijole Gasiunas and John I. Gallagher and Scott Saunders},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 7},
  pages={5604-11}
}
We have reported previously that Noggin is a heparin-binding protein and associates with the cell surface through heparan sulfate proteoglycans, where it remains functional for the binding of bone morphogenetic proteins (BMPs). Here we report that the binding of Noggin to the cell surface is highly selective for heparan sulfate and that specific structural features are required for the interaction. Noggin binds most efficiently to heparin sequences composed of 10 or more monosaccharides; N-, 6… CONTINUE READING
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