Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.

@article{Haggarty2003DomainselectiveSI,
  title={Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.},
  author={Stephen J. Haggarty and Kathryn M. Koeller and Jason C Wong and Christina M Grozinger and Stuart L. Schreiber},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 8},
  pages={4389-94}
}
Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four small-molecule histone deacetylase inhibitors are currently in clinical trials for the treatment of cancer. These and other inhibitors also affect microtubule acetylation. A multidimensional, chemical genetic screen of 7,392 small molecules was used to discover "tubacin," which inhibits alpha-tubulin deacetylation in mammalian cells. Tubacin does not affect the level of… CONTINUE READING
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