Domain-oriented reduction of rule-based network models.

@article{Borisov2008DomainorientedRO,
  title={Domain-oriented reduction of rule-based network models.},
  author={N. M. Borisov and A S Chistopolsky and James R. Faeder and Boris N. Kholodenko},
  journal={IET systems biology},
  year={2008},
  volume={2 5},
  pages={342-51}
}
The coupling of membrane-bound receptors to transcriptional regulators and other effector functions is mediated by multi-domain proteins that form complex assemblies. The modularity of protein interactions lends itself to a rule-based description, in which species and reactions are generated by rules that encode the necessary context for an interaction to occur, but also can produce a combinatorial explosion in the number of chemical species that make up the signalling network. The authors have… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
24 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Sliwkowski, 'Untangling the ErbB signalling network

  • Y. Yarden, M.X
  • Nat. Rev. Mol. Cell Biol.,
  • 2001
Highly Influential
4 Excerpts

Haugh, 'Structure-based Kinetic Models of Modular Signaling Protein Function: Focus on Shp2

  • D. Barua, J. R. Faeder, J.M
  • Biophys . J .
  • 2007

Similar Papers

Loading similar papers…