Domain-oriented reduction of rule-based network models.

  title={Domain-oriented reduction of rule-based network models.},
  author={N. M. Borisov and A S Chistopolsky and James R. Faeder and Boris N. Kholodenko},
  journal={IET systems biology},
  volume={2 5},
The coupling of membrane-bound receptors to transcriptional regulators and other effector functions is mediated by multi-domain proteins that form complex assemblies. The modularity of protein interactions lends itself to a rule-based description, in which species and reactions are generated by rules that encode the necessary context for an interaction to occur, but also can produce a combinatorial explosion in the number of chemical species that make up the signalling network. The authors have… CONTINUE READING

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