Domain organization of the 39-kDa receptor-associated protein.

  title={Domain organization of the 39-kDa receptor-associated protein.},
  author={Leonid Medved and Mary Migliorini and Irina Mikhailenko and Laura G Barrientos and Miguel Llin{\'a}s and Dudley K Strickland},
  journal={The Journal of biological chemistry},
  volume={274 2},
The 39-kDa receptor-associated protein (RAP) is an endoplasmic reticulum resident protein that binds to the low density lipoprotein receptor-related protein (LRP) as well as certain members of the low density lipoprotein receptor superfamily and antagonizes ligand binding. In order to identify important functional regions of RAP, studies were performed to define the domain organization and domain boundaries of this molecule. Differential scanning calorimetry (DSC) experiments revealed that the… CONTINUE READING
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