Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo.

@article{Letsou1993DomainMO,
  title={Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo.},
  author={Anthea Letsou and Stephen Alexander and Steven A. Wasserman},
  journal={The EMBO journal},
  year={1993},
  volume={12 9},
  pages={3449-58}
}
The tube protein plays an essential role in the signal transduction pathway that establishes dorsoventral polarity in the Drosophila melanogaster embryo. Characterization of each of four tube mutants revealed a substitution or insertion in the amino-terminal half of the protein. This portion of the tube protein is also evolutionarily conserved, as demonstrated by isolation and sequencing of the Drosophila virilis tube gene. Moreover, RNA microinjection assays and germline transformation… CONTINUE READING

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A.Letsou, S.Alexander and S.A.Wasserman Niisslein-Volhard,C

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