Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains.

@article{FalcnPrez2001DomainII,
  title={Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains.},
  author={Juan Manuel Falc{\'o}n-P{\'e}rez and M{\'o}nica Mart{\'i}nez-Burgos and Jes{\'u}s Molano and Mar{\'i}a Jos{\'e} Maz{\'o}n and Pilar Eraso},
  journal={Journal of bacteriology},
  year={2001},
  volume={183 16},
  pages={4761-70}
}
The yeast cadmium factor (Ycf1p) is a vacuolar ATP binding cassette (ABC) transporter required for heavy metal and drug detoxification. Cluster analysis shows that Ycf1p is strongly related to the human multidrug-associated protein (MRP1) and cystic fibrosis transmembrane conductance regulator and therefore may serve as an excellent model for the study of eukaryotic ABC transporter structure and function. Identifying intramolecular interactions in these transporters may help to elucidate energy… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Efflux-mediated antifungal drug resistance.

Clinical microbiology reviews • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…