Domain interactions in protein tyrosine kinase Csk.

  title={Domain interactions in protein tyrosine kinase Csk.},
  author={D Sondhi and Philip A Cole},
  volume={38 34},
Csk (C-terminal Src kinase) is a protein tyrosine kinase that phosphorylates Src family member C-terminal tails, resulting in downregulation of Src family members. It is composed of three principal domains: an SH3 (Src homology 3) domain, an SH2 (Src homology 2) domain, and a catalytic domain. The impact of the noncatalytic domains on kinase catalysis was investigated. The Csk catalytic domain was expressed in Escherichia coli as a recombinant glutathione S-transferase-fusion protein and… CONTINUE READING
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