Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.

@article{Songyang2001DomaindependentFO,
  title={Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.},
  author={Zhou Songyang and Yuji Yamanashi and Dan Liu and David Baltimore},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 4},
  pages={
          2459-65
        }
}
p62Dok, the rasGAP-binding protein, is a common target of protein-tyrosine kinases. It is one of the major tyrosine-phosphorylated molecules in v-Src-transformed cells. Dok consists of an amino-terminal Pleckstrin homology domain, a putative phosphotyrosine binding domain, and a carboxyl-terminal tail containing multiple tyrosine phosphorylation sites. The importance and function of these sequences in Dok signaling remain largely unknown. We have demonstrated here that the expression of Dok can… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

The role of DOK7 and its variants in colorectal cancer

VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.

Domain-dependent Function of Dok

N. Jones, D. J. Dumont
  • Curr. Biol
  • 1999
VIEW 2 EXCERPTS