Domain conformation of tau protein studied by solution small-angle X-ray scattering.

@article{Mylonas2008DomainCO,
  title={Domain conformation of tau protein studied by solution small-angle X-ray scattering.},
  author={Efstratios Mylonas and Antje Hascher and Pau Bernad{\'o} and Martin Blackledge and Eckhard Mandelkow and Dmitri I. Svergun},
  journal={Biochemistry},
  year={2008},
  volume={47 39},
  pages={10345-53}
}
Tau is one of the two main proteins involved in the pathology of Alzheimer's disease via formation of beta-sheet rich intracellular aggregates named paired helical filaments (PHFs). Given that tau is a natively unfolded protein with no folded core (even upon binding to physiological partners such as microtubules), its structural analysis by high-resolution techniques has been difficult. In this study, employing solution small-angle X-ray scattering from the full length isoforms and from a… CONTINUE READING

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