Domain-based assays of individual antibody concentrations in an oligoclonal combination targeting a single protein.

@article{Meng2012DomainbasedAO,
  title={Domain-based assays of individual antibody concentrations in an oligoclonal combination targeting a single protein.},
  author={Qi Meng and Miaoxin. Li and M. A. Silberg and Fraser Conrad and J. Moniz De Bettencourt and Rebecca To and Chenglin Huang and Jingya Ma and Kerstin U. Meyer and Rie Shimizu and Li-li Cao and Milan T. Tomic and James D Marks},
  journal={Analytical biochemistry},
  year={2012},
  volume={421 2},
  pages={
          351-61
        }
}
Quantitation of individual monoclonal antibodies (mAbs) within a combined antibody drug product is required for preclinical and clinical drug development, including pharmacokinetic (PK), toxicology, stability, and biochemical characterization studies of such drugs. We have developed an antitoxin, XOMA 3AB, consisting of three recombinant mAbs that potently neutralize the known subtypes of type A botulinum neurotoxin (BoNT/A). The three mAbs bind nonoverlapping BoNT/A epitopes with high affinity… CONTINUE READING
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