Domain atrophy creates rare cases of functional partial protein domains

  title={Domain atrophy creates rare cases of functional partial protein domains},
  author={Ananth Prakash and Alex Bateman},
  booktitle={Genome Biology},
Protein domains display a range of structural diversity, with numerous additions and deletions of secondary structural elements between related domains. We have observed a small number of cases of surprising large-scale deletions of core elements of structural domains. We propose a new concept called domain atrophy, where protein domains lose a significant number of core structural elements. Here, we implement a new pipeline to systematically identify new cases of domain atrophy across all… CONTINUE READING
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