Domain atrophy creates rare cases of functional partial protein domains

@inproceedings{Prakash2015DomainAC,
  title={Domain atrophy creates rare cases of functional partial protein domains},
  author={Ananth Prakash and Alex Bateman},
  booktitle={Genome Biology},
  year={2015}
}
Protein domains display a range of structural diversity, with numerous additions and deletions of secondary structural elements between related domains. We have observed a small number of cases of surprising large-scale deletions of core elements of structural domains. We propose a new concept called domain atrophy, where protein domains lose a significant number of core structural elements. Here, we implement a new pipeline to systematically identify new cases of domain atrophy across all… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 14 times. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Similar Papers

Loading similar papers…