Domain architecture conservation in orthologs

@inproceedings{Forslund2011DomainAC,
  title={Domain architecture conservation in orthologs},
  author={Kristoffer Forslund and Isabella Pekkari and Erik L. L. Sonnhammer},
  booktitle={BMC Bioinformatics},
  year={2011}
}
As orthologous proteins are expected to retain function more often than other homologs, they are often used for functional annotation transfer between species. However, ortholog identification methods do not take into account changes in domain architecture, which are likely to modify a protein's function. By domain architecture we refer to the sequential arrangement of domains along a protein sequence. To assess the level of domain architecture conservation among orthologs, we carried out a… CONTINUE READING
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