Domain and genomic sequence analysis of bdellin-KL, a leech-derived trypsin-plasmin inhibitor.

@article{Kim2001DomainAG,
  title={Domain and genomic sequence analysis of bdellin-KL, a leech-derived trypsin-plasmin inhibitor.},
  author={Y H Kim and Jun Gu Choi and Gyun Min Lee and Keon Wook Kang},
  journal={Journal of biochemistry},
  year={2001},
  volume={130 3},
  pages={431-8}
}
Bdellin-KL is a trypsin-plasmin inhibitor from Hirudo nipponia, whose N-terminal sequence was identified as a non-classical Kazal-type. A cDNA clone encoding the inhibitor was isolated by reverse transcription-PCR and 5' rapid amplification of cDNA ends. The cDNA showed an open reading frame of 155 amino acids comprising one signal peptide and two separated domains. The C-terminal domain consists of distinct internal repeats, including HHEE and HHDD. The bdellin-KL sequence, from the… CONTINUE READING