Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1.

@article{Tu2008DomainAF,
  title={Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1.},
  author={Cheng-Fen Tu and Yu-Ting Yan and S Wu and Bambang Djoko and Ming-Tzu Tsai and C J Cheng and Ruey-Bing Yang},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 18},
  pages={12478-88}
}
SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1) is a novel, secreted, cell surface glycoprotein expressed during early embryogenesis and found in platelet and endothelial cells. This protein is composed of an N-terminal signal peptide sequence followed by nine tandemly arranged epidermal growth factor (EGF)-like repeats, a spacer region, three cysteine-rich repeat motifs, and one CUB domain at the C terminus. However, little is known about its domain and biological function. Here… CONTINUE READING
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