Domain analysis of supervillin, an F-actin bundling plasma membrane protein with functional nuclear localization signals.

@article{Wulfkuhle1999DomainAO,
  title={Domain analysis of supervillin, an F-actin bundling plasma membrane protein with functional nuclear localization signals.},
  author={Julia D. Wulfkuhle and I E Donina and Nicole Stark and Robert K. Pope and Kersi N. Pestonjamasp and M L Niswonger and Elizabeth J. Luna},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 13)},
  pages={2125-36}
}
A growing number of actin-associated membrane proteins have been implicated in motile processes, adhesive interactions, and signal transduction to the cell nucleus. We report here that supervillin, an F-actin binding protein originally isolated from bovine neutrophil plasma membranes, contains functional nuclear targeting signals and localizes at or near vinculin-containing focal adhesion plaques in COS7-2 and CV1 cells. Overexpression of full-length supervillin in these cells disrupts the… CONTINUE READING

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