Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels

@inproceedings{Capes2013DomainIV,
  title={Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels},
  author={Deborah L. Capes and Marcel P. Goldschen-Ohm and Manoel Arcisio-Miranda and Francisco Bezanilla and Baron Chanda},
  booktitle={The Journal of general physiology},
  year={2013}
}
Voltage-gated sodium channels are critical for the generation and propagation of electrical signals in most excitable cells. Activation of Na(+) channels initiates an action potential, and fast inactivation facilitates repolarization of the membrane by the outward K(+) current. Fast inactivation is also the main determinant of the refractory period between… CONTINUE READING