Domain Both Inhibits and Stimulates PDZ Binding Threonine Phosphorylation of the MMAC 1 / PTEN PDZ Binding

Abstract

Two-hybrid searches with the tumor suppressor MMAC1/PTEN isolated the proteins hDLG and hMAST205. Further two-hybrid analysis and microtiter plate binding assays localized the sites of interaction to PDZ domains from hDLG and hMAST205 and the PDZ binding domain at the COOH terminus of MMAC1/PTEN. A synthetic peptide derived from the MMAC1/PTEN PDZ binding… (More)

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