Domain Altering SNPs in the Human Proteome and Their Impact on Signaling Pathways

Abstract

Single nucleotide polymorphisms (SNPs) constitute an important mode of genetic variations observed in the human genome. A small fraction of SNPs, about four thousand out of the ten million, has been associated with genetic disorders and complex diseases. The present study focuses on SNPs that fall on protein domains, 3D structures that facilitate… (More)
DOI: 10.1371/journal.pone.0012890

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