Domain 1 of the urokinase receptor (uPAR) is required for uPAR-mediated cell binding to vitronectin.

@article{Sidenius2000Domain1O,
  title={Domain 1 of the urokinase receptor (uPAR) is required for uPAR-mediated cell binding to vitronectin.},
  author={Nicolai Sidenius and Francesco Blasi},
  journal={FEBS letters},
  year={2000},
  volume={470 1},
  pages={40-6}
}
In the present paper we have analyzed uPAR-mediated cellular binding to vitronectin using the murine erythroid progenitor cell line 32D. We show that expression of uPAR in 32D cells promotes cellular binding to vitronectin, but fails to support cell spreading. The strength of binding is correlated to the expression level of uPAR and is strongly stimulated by the presence of uPAR ligands. Using a truncated variant of uPAR lacking domain 1 and by antibody inhibition experiments, we demonstrate… CONTINUE READING

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