Domain–domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel

@inproceedings{Zaydman2014DomaindomainID,
  title={Domain–domain interactions determine the gating, permeation,
pharmacology, and subunit modulation of the IKs ion channel},
  author={Mark A. Zaydman and Marina A Kasimova and Kelli McFarland and Zachary Beller and Panpan Hou and Holly E Kinser and Hongwu Liang and Guohui Zhang and Jingyi Shi and Mounir Tarek and Jianmin Cui},
  booktitle={eLife},
  year={2014}
}
Voltage-gated ion channels generate electrical currents that control muscle contraction, encode neuronal information, and trigger hormonal release. Tissue-specific expression of accessory (β) subunits causes these channels to generate currents with distinct properties. In the heart, KCNQ1 voltage-gated potassium channels coassemble with KCNE1 β-subunits to generate the IKs current (Barhanin et al., 1996; Sanguinetti et al., 1996), an important current for maintenance of stable heart rhythms… CONTINUE READING
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